Organosulfur and Organoboron Chemistry

Sulfur and boron are central to medicinal chemistry and organic synthesis. We focus on underexplored reactivity of sulfur and boron to discover new mechanisms that facilitate chemo- and stereoselective introduction of boron and sulfur functionalities in complex molecular settings. Our photoinduced and photocatalytic borylation methods can be used to synthesize boronates from a wide range of aromatic and heteroaromatic halides, as well as derivatives of phenols with reduction potentials as low as 3 V.

We have also developed methods for the synthesis of organosulfur compounds by functionalization of C–H bonds and other common precursors. These methods provide synthetic shortcuts to thiols, sulfinates, sulfoxides, sulfones, sulfinamides, sulfonamides, and other medicinally and synthetically valuable functional groups.